Bharath Srinivasan Author

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Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts

Author(s): Harika Puppala Satya Krishna, Bharath Srinivasan, Deveswaran Rajamanickam, Basavaraj Basappa Veerabhadraiah and Madhavan Varadharajan

Solubility and Dissolution Enhancement of Candesartan Cilexetil by Liquisolid Compacts

Candesartan cilexetil belong to the class angiotensin-II receptor antagonist used in the treatment of hypertension. It is practically insoluble in water, belongs to a BCS class-II and its half life is 5.1 h with bioavailability of 15 - 40%. The aim of this study was to investigate the use of liquisolid technique in improving the dissolution profile of candesartan cilexetil. The liquisolid tablets were formulated using a non-volatile liquid vehicle PEG 400 at three drug concentrations of 40%, 50% and 60% w/w and at an excipient ratio of 10, 20 and 30 using methyl cellulose 4000 cps and d... view more»

DOI: 10.4172/2325-9604.1000115

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