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Hindi Clinical Oncology: Case Reports
Brahmbhatt Manisha M Author
Subjects of specialization
Affiliation
Molecular Biology of Cancer ,Thoracic Cancer,Molecular Tumor,Ovarian Cancer,Targeted Therapy Immuno-Oncology
Cytogenetic Lab, Department of Cancer Biology, Gujarat Cancer & Research Institute, Asarwa, Ahmedabad-380016, India
Biography
Dr. Manisha is a visiting Scientist for exchange of expertise at Genomedica laboratory, Greece, for one month March - 2009. Chromosomes are my passion! The main research focus is to first obtain overview of the genomic changes acquired by the neoplastic cells by cytogenetic screening methods and then extending the search for the pathogenetic, diagnostic, and prognostic meaning of these changes to the molecular level. Further, to explore its applications in Translational Cancer Research and for identification of Newer Drug Targets using state-of-the-art technology and various testing algorithms.
Publications
Research Article Open Access
A Sole Cytogenetic Abnormality r (2) in Acute Lymphocytic Leukemia Patient: An Indian Experience
Author(s): Patel Dharmesh M, Trivedi Pina J, Brahmbhatt Manisha M and Patel Prabhudas S* (India)
Cytogenetic abnormalities are established as important prognostic factor for Leukemia. After the first report of a ring chromosome in a case of human leukemia ring chromosomes have been infrequently (<10%) detected in hematopoietic neoplasias. However, ring chromosomes are part of complex karyotype associated with a poor prognosis. In this study we document a case of 21 years old Acute Lymphoblastic Leukemia (ALL) patient. Short term unstimulated bone marrow (BM) and peripheral blood lymphocyte cultures were performed. The karyotype report was 46, XY, r (2)(p23-25q33-37). Fluorescence in-situ hybridization using WCP for chromosome 2 confirmed presence of ring chromosome 2. In most cases, there are no confirmatory reports on an association between a specific leukemia subtypes with rin... view more»