Dabboubi Rym Author

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Association Study of IVS8TGmTn Polymorphism and Cystic Fibrosis Disease in a Tunisian Population

Author(s):

Sahli Chaima, Hadj Fredj Sondess, Dabboubi Rym, Bousseta Khedija, Mehrzi Ahmed, Messaoud Taieb

Background: Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians, caused by mutation in cystic fibrosis transmembrane conductance regulator (CFTR). The analysis of some extra and intragenic markers within or closely linked to CFTR gene  is  useful  as  a  molecular  method  in  clinical  linkage  analysis.  Indeed, knowing that the molecular basis of CF is highly heterogeneous in our population is explained in the present study. The goal of the study was to examine the IVS8 TGmTn genotypes in a Tunisian sample of patients with CF disease and normal controls, and to compare the results with the findings from the literature.

Methods: We conducted a case–control... view more»

DOI: 10.4172/2327-5790.1000147

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