El-hagrasy Arwa Author

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Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique

Author(s): Salah Ibtehal, El-gazayerly Omaima, El-hagrasy Arwa and Abdel Bary Ahmed

Preparation of Zaleplon Microparticles Using Emulsion Solvent Diffusion Technique

Zaleplon is a BCS class II drug suffering from poor solubility. In a trial to improve its dissolution, emulsion solvent diffusion method (ESD) was used to prepare zaleplon microparticles using sodium lauryl sulfate (SLS) as surfactant. Optimization of drug system was achieved. Particle size values of the prepared microparticles were ranged from 6.57 μm to 20.30 μm with narrow particle size distribution range. Differential scanning calorimetry (DSC) and x-ray diffraction (XRD) were used for the characterization of the prepared systems. DSC and XRD patterns showed that the zaleplon mic... view more»

DOI: 10.4172/2325-9604.1000108

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