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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Emmanuel O. Akala Author
Subjects of specialization
Affiliation
Anti-HDV antibodies;
Emmanuel O. Akala, R. Ph., Ph.D. is a Professor of Pharmaceutics, Chair, Howard University Institutional Animal Care and Use Committee (IACUC)
Biography
Emmanuel O. Akala, R. Ph., Ph.D. is a Professor of Pharmaceutics, Chair, Howard University Institutional Animal Care and Use Committee (IACUC) and Director, Laboratory for Nanomedicine, Drug Delivery, and Pharmaceutical & Biopharmaceutical Drug Products Design. His training is cosmopolitan and his curriculum vitae (CV) provides details of his professional training as a pharmacist and an immunization pharmacist (registered in Utah, Maryland, Washington DC and in Nigeria), a pharmacy professor, and a research scientist with bias for conventional and novel drug delivery systems.
Publications
Research Article Open Access
Fabrication of Paclitaxel and 17AAG-loaded Poly-É›- Caprolactone Nanoparticles for Breast Cancer Treatment
Author(s): Yvonne Abbey Berko, Funmilola A. Fisusi , Emmanuel O. Akala
Objective: The aim of this study is to design, fabricate and determine the cytotoxic effects of dual loaded paclitaxel and 17-AAG in stealth polymeric nanoparticles. The nanoparticles were fabricated by dispersion polymerization. Methods: Two breast cancer cell lines (MCF-7 and SKBR-3) were cultured and treated with media only, blank nanoparticles, paclitaxel (as a free drug), 17-AAG (free drug), paclitaxel + 17- AAG combination (as free drugs), and paclitaxel + 17-AAG combination loaded in poly-É›-caprolactone stealth nanoparticles. Each drug in the combination was half the concentration of the single free drug. Results: The cytotoxic effects of the paclitaxel treatment and that of the combination (free drug) were found to be similar in both SKBR3 and MCF7 cell lines. Similar cytoto... view more»
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