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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Fatih M Uckun Author
Subjects of specialization
Affiliation
Cancer Therapy
Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.
Biography
Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.
Publications
Review Article Open Access
Targeting Spleen Tyrosine Kinase (Syk) for Treatment of Human Disease
Author(s): Osmond J D Cruz and Fatih M Uckun
Targeting Spleen Tyrosine Kinase (Syk) for Treatment of Human Disease
Spleen tyrosine kinase (SYK) plays a crucial role in the coordination of immune recognition receptors and orchestrates multiple downstream signaling pathways in various hematopoietic cells. In addition to its well-known function in transducing Fcγ receptor- and B cell receptor-mediated events, SYK signals downstream of a growing list of immunoreceptor pathways that modulate the innate and adaptive responses.
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