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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Funmilola A. Fisusi Author
Subjects of specialization
Affiliation
Pharmaceutical Sciences,
Center for Drug Research and Development, Department of Pharmaceutical Sciences, College of Pharmacy, Howard University,
Biography
Center for Drug Research and Development, Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, 2300 4th Street, NW, Washington, DC 20059, USA. Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Publications
Research Article Open Access
Fabrication of Paclitaxel and 17AAG-loaded Poly-É›- Caprolactone Nanoparticles for Breast Cancer Treatment
Author(s): Yvonne Abbey Berko, Funmilola A. Fisusi , Emmanuel O. Akala
Objective: The aim of this study is to design, fabricate and determine the cytotoxic effects of dual loaded paclitaxel and 17-AAG in stealth polymeric nanoparticles. The nanoparticles were fabricated by dispersion polymerization. Methods: Two breast cancer cell lines (MCF-7 and SKBR-3) were cultured and treated with media only, blank nanoparticles, paclitaxel (as a free drug), 17-AAG (free drug), paclitaxel + 17- AAG combination (as free drugs), and paclitaxel + 17-AAG combination loaded in poly-É›-caprolactone stealth nanoparticles. Each drug in the combination was half the concentration of the single free drug. Results: The cytotoxic effects of the paclitaxel treatment and that of the combination (free drug) were found to be similar in both SKBR3 and MCF7 cell lines. Similar cytoto... view more»
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