Clinical Oncology: Case Reports

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Gary C Doolittle Author

gdoolitt@kumc.edu

Subjects of specialization
cancer, cancer oncology, Carcinogenesis, Palliative Medicine Hospice Hospice Care End-of-Life Care

Affiliation
Division of Clinical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Kansas City, KS, USA

Biography

Dr. Gary C Doolittle is working as scientist and professor at Division of Clinical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Kansas City, KS, USA. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy

Publications

Case Report Open Access

A Case Report of Acute Myeloid Leukemia in a Patient Treated with Pembrolizumab

Author(s):

John Chazhoor, Jodie A Barr, and Gary C Doolittle

We report the case of a 68-year old male who presented with worsening epigastric pain and complaints of early satiety. CT abdomen indicated widespread hepatic metastatic disease. The primary malignancy was diagnosed as unresectable cholangiocarcinoma. The patient underwent various conventional chemotherapy and localized radiotherapy, all of which proved ineffective in reducing disease burden. Checkpoint inhibitor pembrolizumab (Keytruda®) was eventually administered. While treatment was effective in decreasing disease burden, fourteen months into treatment with the anti-PD-1 therapy, signs of bone marrow insufficiency became apparent. Bone marrow biopsy revealed leukemic blast cells leading to a suspicion of therapy-related Acute Myeloid Leukemia (AML). We suspect pembrol... view more»

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