Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533

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George Oche Ambrose Author

ocheab1@gmail.com

Subjects of specialization
Cheminformatics and Computational Chemistry, Molecular Dynamics Simulation, Molecular Docking, Drug Discovery

Affiliation
Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

Biography

George Oche Ambrose is currently working as a research Officer from the Department of Biochemistry University of Ilorin, Ilorin Nigeria. previously he worked in Ben Carson School of Medicine, Ileshan-Remo, Nigeria. He is having more than 28 publications and his current reserach interts includes Lung Cancer, Screening, Cancer Biomarkers, Metastasis, Cancer Biology, Molecular Modeling.

Publications

Research Article Subscription

In silico Sequence Analysis, Homology Modeling and Function Annotation of Farnesyl Diphosphate Synthase (FDS) of Azadirachta indica

Author(s):

George Oche Ambrose, Olanrewaju John Afees, Alakanse Suleiman Oluwaseun, Chia Terkuma, Mtomga Iorwuese, Ayuba Abdullateef Kayode, Balogun Basheer Ajibola, Abiodun Wisdom Oshireku, Afolayan Daniel Todimu, Fagbemi Ranti- Ade Rebecca and Adekunle Precious

Azadirachta indica is commonly referred to as Neem and is a member of the mahogany family, Meliaceae. Azadirachta indica has enormous therapeutic benefits and can show antibacterial activity, antiviral activity, anti-inflammatory activity, antioxidant effect and anticarcinogenic activity. Hence, it is recognized as a tree for solving global health problems. In the present study, subcellular localization prediction reveals that FDS of Azadirachta indica is a cytoplasmic protein. We predicted the 3D structure of the protein using homology modeling as 3D structure prediction methodology. The 3D structure of FDS was determined using SwissModel. Quality assessment of the model indicated that the model is reliable. Furthermore, it was discovered that FDS is involved in biological processes; m... view more»

DOI: 10.4172/2329-9533.1000157

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