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Hindi Clinical Oncology: Case Reports
Harriet M Kluger Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Section of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biography
Dr. Harriet M Kluger is working as scientist and professor at DSection of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Mycophenolate as Primary Treatment for Immune Checkpoint Inhibitor Induced Acute Kidney Injury in a Patient with Concurrent Immunotherapy-Associated Diabetes: A Case Report
Author(s): Shlomit Jessel, Mathew Austin and Harriet M Kluger
Immune checkpoint inhibitors enhance T cell response against malignant cells and are standard of care in many tumor types. Disinhibition of cytotoxic T cells in normal organs and inhibitrion of regulatory T cells can lead to immune-related adverse events. Here we describe a 60-year-old man with metastatic melanoma treated with three cycles of nivolumab and ipilimumab. He subsequently presented with new-onset brittle diabetes, rash, fever, and acute kidney injury. After initiation of insulin and aggressive fluid resuscitation, his kidney function transiently improved but then dramatically worsened.
Due concerns regarding hyperglycemia, a steroid-sparing agent was necessary and he was successfully treated with front-line mycophenolate mofetil, leading to normalization of renal f... view more»
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