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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Hoang D Lu Author
Subjects of specialization
Affiliation
Human brucellosis;
Departments of Chemical Engineering and Chemistry and Biochemistry, Center for Electrochemistry, Texas Materials Institute,
Biography
My name is Hoang D Lu I am from Departments of Chemical Engineering and Chemistry and Biochemistry, Center for Electrochemistry, Texas Materials Institute, Center for Nano- and Molecular Science, University of Texas at Austin, 1 University Station C0400, Austin, Texas 78712-0231, United States My area of interests are Human brucellosis;
Publications
Research Article Open Access
Application of Acoustic- Vibratory Milling For Screening and Scale-Up of Micro/ Nanosuspensions in Early Drug Discovery and Development
Author(s): Hoang D Lu
Current methods of milling an active pharmaceutical ingredient (API) often suffer from limited control over particle size and solid-state form or require large amounts of material for optimization, rendering them unsuitable for use in early discovery efforts. We here develop operating workflows of an acoustic-vibratory milling technique, which enables both materials-sparing screens and scaled-up production of micro/nanosuspensions with well-defined and tunable particle size distributions. Workflows are based on the generation of guidance maps for API insensitive outputs (temperature) and API dependent outputs (particle size), with various operational parameters for milling such as container headspace, container geometry, milling media load & size, m... view more»
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