Journal of Genital System & DisordersISSN: 2325-9728

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Joffe M Author

m.joffe@imperial.ac.uk

Subjects of specialization
Semen quality; Infertility; Embryo loss; Aneuploidy; Testicular cancer; Sperm DNA damage; Meiosis; Aneuploidy relationship with maternal age

Affiliation
Department of Epidemiology and Biostatistics, St Mary

Biography

Joffe M is working in a Department of Epidemiology and Biostatistics, St Mary’s Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom. He has published more number of articles and he has the good knowledge in Cesarean scar pregnancy; Ectopic pregnancy; Treatment.

Publications

Review Article Open Access

What is Wrong with the Human Reproductive System?

Author(s):

Joffe M

What is Wrong with the Human Reproductive System?

Human reproduction is highly inferior by mammalian standards. This is manifest as: (i) poor semen quality; (ii) a lower probability of conception; (iii) an increased risk of aneuploidy embryos (e.g. Down syndrome); (iv) a high risk of embryonic loss (early miscarriage); and (v) the recent rise of germ-cell testicular cancer, which occurs in few non-human mammalian species. Review and synthesis of the evidence from several distinct research areas reveals a shared pathogenesis underlying at least some cases of all of them. This involves an intergenerational process, starting with DNA damage to round spermatids. DNA repair in the ooc... view more»

DOI: 10.4172/2325-9728.S2-002

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