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Hindi Clinical Oncology: Case Reports
John Chazhoor Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
University of Kansas School of Medicine, Kansas City, KS, USA
Biography
Dr. John Chazhoor is working as scientist and professor at University of Kansas School of Medicine, Kansas City, KS, USA. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
A Case Report of Acute Myeloid Leukemia in a Patient Treated with Pembrolizumab
Author(s): John Chazhoor, Jodie A Barr, and Gary C Doolittle
We report the case of a 68-year old male who presented with worsening epigastric pain and complaints of early satiety. CT abdomen indicated widespread hepatic metastatic disease. The primary malignancy was diagnosed as unresectable cholangiocarcinoma. The patient underwent various conventional chemotherapy and localized radiotherapy, all of which proved ineffective in reducing disease burden. Checkpoint inhibitor pembrolizumab (Keytruda®) was eventually administered. While treatment was effective in decreasing disease burden, fourteen months into treatment with the anti-PD-1 therapy, signs of bone marrow insufficiency became apparent. Bone marrow biopsy revealed leukemic blast cells leading to a suspicion of therapy-related Acute Myeloid Leukemia (AML). We suspect pembrol... view more»
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