Khalida Naveed Author

Research Article Open Access

A Computational Approach for Mutational Analysis of KRAS Snps and Toxicity Prediction of Screened Compounds of Lethal G12R KRAS SNP

Author(s):

Fareha Masood, Khalida Naveed and Syeda Tatheer Fatima

KRAS protein is vital for normal cell signaling and its single point mutations are linked with the development of numerous forms of malignancies. Despite of various reports available on SNPs of KRAS and its unresponsiveness to available drug therapies, there is an urgent need for the development of effective and potential drug target against it. In present study, a strategy is made with the combination of computational biology, cancer informatics and cheminformatics. Mutational analysis, structure based virtual screening (SBVS) and toxicity profiling of compounds have been performed for the prediction of therapeutic drug targets against KRAS detrimental mutations. Among 31 retrieved mutations from dbSNP and UniProt, 12 mutations were predicted to be lethal by PROVEAN and PolyPhen tools.... view more»

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