Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477

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Konstantin A Lyssenko Author

sheverdovvp@yandex.ru

Subjects of specialization
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy

Affiliation
AN Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Science, Russia

Biography

Konstantin A Lyssenko; AN Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Science, Russia. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology

Publications

Research Article Open Access

Synthesis, Antiproliferative Activity of Nitrile Containing Pyranes and 1,2,5,6,7,8-Hexahydroquinoline-3,3,4,4-Tetraсarbonitriles

Author(s):

Vladimir P Sheverdov, Maksim A Maryasov, Vera V Davydova, Oleg E Nasakin and Konstantin A Lyssenko

lMethyl 6-Amino-3-acyl-4-aryl-5-cyano-4H-pyran-2-carboxylates, 9-aryl-12-imino-10,11 dioxatricyclo-[5.3.2.01,6]-dodecan-7,8,8- tricarbonitriles, 2-R-1,2,5,6,7,8-hexahydroquinoline-3,3,4,4- tetraсarbonitriles were synthesized. The antiproliferative activity of obtained compounds was investigated. At a concentration of 10 μM test substances activity higher than that of the drug busulfan and cisplatin showed a compounds containing in its composition fragment of ethyl 1,1,2,2-tetracarbonitrile - 2-R-1,2,5,6,7,8- hexahydroquinoline-3,3,4,4-tetraсarbonitriles.

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DOI: 10.4172/2380-9477.1000114

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