Journal of Pharmaceutical Sciences & Emerging Drugs ISSN: 2380-9477

Research Article, J Pharm Sci Emerg Drugs Vol: 4 Issue: 2

Synthesis, Antiproliferative Activity of Nitrile Containing Pyranes and 1,2,5,6,7,8-Hexahydroquinoline-3,3,4,4-Tetraсarbonitriles

Vladimir P Sheverdov1*, Maksim A Mar’yasov1, Vera V Davydova1, Oleg E Nasakin1 and Konstantin A Lyssenko2
1Chuvash State University, Cheboksary- 428015, Russia
2AN Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Science, Russia
Corresponding author : Vladimir P Sheverdov
Chuvash State University,Cheboksary-428015, Russia
E-mail: [email protected]
Received: October 24, 2016 Accepted: November 02, 2016 Published: November 09, 2016
Citation: Sheverdov VP, Mar’yasov MA, Davydova VV, Nasakin OE, Lyssenko KA (2016) Synthesis, Antiproliferative Activity of Nitrile Containing Pyranes and 1,2,5,6,7,8-Hexahydroquinoline-3,3,4,4-Tetraсarbonitriles. J Pharm Sci Emerg Drugs 4:2. doi: 10.4172/2380-9477.1000114


lMethyl 6-Amino-3-acyl-4-aryl-5-cyano-4H-pyran-2-carboxylates, 9-aryl-12-imino-10,11 dioxatricyclo-[,6]-dodecan-7,8,8- tricarbonitriles, 2-R-1,2,5,6,7,8-hexahydroquinoline-3,3,4,4- tetra?arbonitriles were synthesized. The antiproliferative activity of obtained compounds was investigated. At a concentration of 10 μM test substances activity higher than that of the drug busulfan and cisplatin showed a compounds containing in its composition fragment of ethyl 1,1,2,2-tetracarbonitrile - 2-R-1,2,5,6,7,8- hexahydroquinoline-3,3,4,4-tetra?arbonitriles.

Keywords: Pharmacophore; Ethyl 1,1,2,2-tetracarbonitrile fragment;Tetracyanoethylene; Antipro-liferative activity

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