Krista Bossi Author

Research Article Open Access

Estimates of Glomerular Filtration Rate in Liver Transplant Recipients are not Accurate: A Role for 24-Hour Urine Creatinine Clearance

Author(s):

Mark W Russo, Krista Bossi, Gale Groseclose, David M Levi, Lon Eskind, Bennett Noell, Anderson WE, Philippe J Zamor and Vincent Casingal

Background: Kidney injury is common among liver transplant recipients. Equations estimating glomerular filtration rate were not developed in liver transplant recipients. Aim: To determine if GFR equations and 24-hour urine creatinine clearance accurately estimate GFR in liver transplant recipients. Methods: 30 subjects were enrolled within 6 months of transplant and obtained estimates of GFR. The iothalamate scan served as the gold standard and it was compared to GFR equations and 24- hour urine creatinine clearance. Results: The mean time to iothalamate scan was 110 + 50 days.The mean iothalamate GFR was 90 + 37 mL/min/1.73 m2. The GFR equations underestimated GFR with 47%-63% of estimates differing by more than 20% from the iothalamate GFR. Among the equations the CKD-EPI-Cys-Cr was t... view more»

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