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Hindi Clinical Oncology: Case Reports
Lindsey Addington Author
Subjects of specialization
Affiliation
Metastatic adrenocortical carcinoma,Immunotherapy,Pembrolizumab
Diagnostic Radiology, Community Hospital Cancer Center, 1440 East County Line Road Indianapolis
Biography
Dr. Addington works in Indianapolis, IN and 1 other location and specializes in Medical Oncology and Nurse Practitioner. Ms. Addington is affiliated with Franciscan Saint Francis Health, Community Hospital East, Community Health Network South Campus, Community Hospital North and Community Hospital North
Publications
Case Report Open Access
Impressive Response to Immunotherapy in a Patient with Metastatic Adrenocortical Carcinoma
Author(s): Lindsey Addington*, Hagman Thomas, Hawk, Nicole CMA and Pablo Bedano (USA)
Adrenocortical carcinoma (ACC) is a rare cancer with limited effective treatment options and poor prognosis. ACC incidence is 1 to 2 cases per million making randomized clinical trials difficult to conduct. The current standard first line treatment for metastatic ACC showing tumor response and improved progression free survival (PFS) is etoposide-doxorubicin-cisplatin (EDP) plus mitotane. Multiple efforts to find a targeted treatment for ACC have not shown impressive responses. Immunotherapy agents such as checkpoint inhibitors programmed cell death – 1 receptor (PD-1) and programmed cell deathligand 1 have shown significant responses in multiple malignancies including melanoma, non-small-cell-lung cancer, Hodgkin’s lymphoma to name a few. We present a case of a female patie... view more»
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