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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Luitpold V. R. Distel Author
Subjects of specialization
Affiliation
Cell Biology, Immunology, Cancer Research, Lymphocytes, Cancer Biology
Department of Radiation Oncology, Friedrich-Alexander University of Erlangen-Nuremberg, Universit
Biography
Luitpold V. R. Distel is head of the Radiation Biology Group and we focus on patients? individual radiosensitivity to adjust radiation doses for oncological patients. We study tumor infiltrating lymphocytes in tumor tissues to evaluate the prognostic value, especially in immunosuppressing mechanisms by regulatory T-cells and there interactions with other cells. He study the interactions of chemotherapeutics and kinase inhibitors with ionizing radiation. Another focus is the non-professional phagocytosis.
Publications
Research Article Subscription
Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
Author(s): Stefanie Klein, Anja Sommer, Maria L. Dell’Arciprete, Marc Wegmann, Susanne V. Ott, Luitpold V. R. Distel, Winfried Neuhuber, Mónica C. Gonzalez, and Carola Kryschi
Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of ... view more»
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