Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Research Article, J Nanomater Mol Nanotechnol S Vol: 0 Issue: 2

Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy

Stefanie Klein1*, Anja Sommer1, Maria L. Dell’Arciprete2, Marc Wegmann1, Susanne V. Ott1, Luitpold V. R. Distel3, Winfried Neuhuber4, Mónica C. Gonzalez2, and Carola Kryschi2
1Department of Chemistry and Pharmacy, Physical Chemistry I and ICMM,Friedrich-Alexander University of Erlangen-Nuremberg, Egerlandstr.3, D-91058 Erlangen, Germany
2Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Casilla de Correo 16, Sucursal 4, (1900) La Plata, Argentina
3Department of Radiation Oncology, Friedrich-Alexander University of Erlangen-Nuremberg, Universitätsstr. 27, D-91054 Erlangen, Germany
4Department of Anatomy, Chair of Anatomy I, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstr. 9, D-91054 Erlangen, Germany
Corresponding author : Dr. Stefanie Klein
Department of Chemistry and Pharmacy, Physical Chemistry I and ICMM, Friedrich-Alexander University of Erlangen-Nuremberg, Egerlandstr.3, D-91058 Erlangen, Germany
Tel: ++49 (0)9131 / 85-27508; Fax: ++49 (0)9131 / 85-28796
E-mail: [email protected]
Received: April 25, 2014 Accepted: June 16, 2014 Published: June 20, 2014
Citation: Klein S, Sommer A, Dell’Arciprete ML, Wegmann M, Ott SV, et al. (2014) Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy. J Nanomater Mol Nanotechnol S2:002. doi:10.4172/2324-8777.S2-002

Abstract

Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy

Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.

Keywords: Silicon nanoparticles; Superparamagnetic iron oxide nanoparticles; Radiation therapy; Reactive oxygen species generation

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