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Hindi Clinical Oncology: Case Reports
Marc Bonnefoy Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Geriatric Unit, Lyon-Sud University Hospital, Pierre-B
Biography
Dr. Marc Bonnefoy is working as scientist and professor at Geriatric Unit, Lyon-Sud University Hospital, Pierre-Bénite, France. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Gemcitabine Cardiotoxicity: Two Case Report and Review of the Literature
Author(s): Marie Valero, Thomas Gilbert, Chauvenet, Anissa Bouali, Marc Bonnefoy and Claire Falandry
Gemcitabine is a chemotherapy treatment that is generally well tolerated, also in elderly patients. In Phases 1 and 2 clinical studies, there was no increased risk of cardiac toxicity. However, in our clinical practice, we have managed two patients in their nineties with cardiovascular events on gemcitabine : one patient with a heart attack and arrhythmia, the other patient in heart decompensation on a paroxysmal arrhythmia. In the literature, there are 15 cases of cardiovascular events on gemcitabine monotherapy and 6 cases on gemcitabine in combination with a platinum salt. The cardiotoxicity of gemcitabine in the elderly is underestimated due to comorbidities and multidrug therapy. Gemcitabine may be a potential cause although the exact mechanism rema... view more»
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