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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Mark A Korsten Author
Subjects of specialization
Affiliation
Transdermal drug administration
Departments of Medicine, Medical Service James J. Peters VA Medical Center, Bronx NY, United States
Biography
Mark A Korsten- Veterans Affairs Rehabilitation Research & Development Service’s National Center for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, Bronx, NY, United States, Departments of Medicine, Medical Service James J. Peters VA Medical Center, Bronx NY, United States, Departments of Medicine Medical Service James J. Peters VA Medical Center, Bronx NY, United States
Publications
Research Article Open Access
A Comparison among Three Skin Preparations for the Transdermal Delivery of Vitamin B12 by Iontophoresis: A Novel Approach to Determine Systemic Absorption
Author(s): Anton V Sabiev, Mark A Korsten, and William A Bauman
Background: Poor skin permeability precludes the use of the transdermal route for the administration of most medications that require entry into the systemic circulation. However, charged compounds may be delivered systemically by Iontophoresis (ION). The relative safety and efficacy of the transdermal delivery of vitamin B12 (Methylcobalamin) by ION was determined by testing three different skin preparations. Subjects and Methods: Vitamin B12 15 mg was transdermally administered to 8 healthy subjects after the skin was prepared for ION delivery by three methods that were performed on each subject in a random order 1. Cleaning the skin with isopropyl alcohol (control) 2. Epilation followed by cleaning the skin with isopropyl alcohol 3. Pre-soaking the skin with oleic acid followed by cl... view more»
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