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Hindi Clinical Oncology: Case Reports
Mitsuhiro Morikawa Author
Subjects of specialization
Affiliation
Surgery ,Medical Oncology,, Molecular Tumor, ,Targeted Therapy , Immuno-Oncology
Department of Surgery I, University of Fukui, Eiheiji 910-1193, Japan
Biography
Dr. Mitsuhiro Morikawa is a research scientist and Professor at Department of Surgery I, University of Fukui, Eiheiji 910-1193, Japan. Dr. Mitsuhiro Morikawa having specialization in Surgery Medical Oncology, Molecular Tumor, Targeted Therapy Immuno-Oncology
Publications
Case Report Open Access
Positive Response to Dual BRAF and MEK Inhibition in a Case with BRAF Mutant Anorectal Malignant Melanoma
Author(s): Hidetaka Kurebayashi*, Takanori Goi, Mitsuhiro Morikawa, Kenji Koneri, Masato Tamaki, Makoto Murakami, Yasuo Hirono and Kanji Katayama (Japan)
A 59-year-old male with the chief complaint of bloody stool underwent transanal tumor resection for an anorectal malignant melanoma. Rectal amputation and inguinal lymph node dissection were not performed due to severe anemia with platelet depression and poor general condition. After the operation, treatment with an immune checkpoint inhibitor was started. A gait disturbance was diagnosed as postoperative inflammatory neuropathy based on a nerve biopsy. As steroid treatment was necessary, the immune checkpoint inhibitor was discontinued after a single dose. Tissue diagnosis identified the BRAF gene mutation, and combination therapy with dabrafenib/trametinib was started. Abdominal contrast computed tomography on day 30 and 101 after the start of medication showed decreased right inguina... view more»