Nashwa Shible Author

Research Article Open Access

Metalloproteinase Inhibitor-1 Closely Correlates With the Severity of Liver Disease in Egyptian Patients

Author(s):

Khaled Metwally, Tamer Fouad, Nashwa Shible, Hassan Zaghla, Eman Abdel sameea, Mona M.Aref and Fatma A. Khalaf

Background: Liver disease prevalence is high in Egypt and finding a reliable seromarker is needed for diagnosis and prognosis of fibrosis. Tissue inhibitor of metalloproteinase -1 (TIMP-1) previously showed a good relation with fibrosis but few data are available from Egypt.
Objective: To test the correlation of TIMP-1 to the degree of liver fibrosis in Egyptian patients with and without cirrhosis, and to test its values in different degrees of liver dysfunction.
Methods: Forty Six adult patients (31 males and 15 females) with chronic liver disease were included in the current study, with age ranged from 42 –63 years were recruited from outpatient clinics at the National Liver Institute, Menoufiya University from February to J... view more»

DOI: 10.4172/2325-9612.1000157

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