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Hindi Clinical Oncology: Case Reports
Nicole CMA Author
Subjects of specialization
Affiliation
Acute Leukemia ,Acute Lymphocytic, Leukemia Acute Myelogenous Leukemia,Acute Myeloid Leukemia Chronic ,Leukemia Chronic Lymphocytic
Associate Professor of Medicine at CUMC
Biography
" Nicole Lamanna, MD, is an Associate Clinical Professor of Medicine in the Hematologic Malignancies Section of the Hematology/Oncology Division. Dr. Lamanna is a hematologist/oncologist whose research interests include lymphoid leukemias, specifically chronic lymphocytic leukemia. She is an experienced clinical investigator and her research focus has been the development of combination therapies that include chemoimmunotherapy, immunomodulatory drugs, novel kinase inhibitors and monoclonal antibodies. She also is working to find active, safer therapies for older patients with these diseases."
Publications
Case Report Open Access
Impressive Response to Immunotherapy in a Patient with Metastatic Adrenocortical Carcinoma
Author(s): Lindsey Addington*, Hagman Thomas, Hawk, Nicole CMA and Pablo Bedano (USA)
Adrenocortical carcinoma (ACC) is a rare cancer with limited effective treatment options and poor prognosis. ACC incidence is 1 to 2 cases per million making randomized clinical trials difficult to conduct. The current standard first line treatment for metastatic ACC showing tumor response and improved progression free survival (PFS) is etoposide-doxorubicin-cisplatin (EDP) plus mitotane. Multiple efforts to find a targeted treatment for ACC have not shown impressive responses. Immunotherapy agents such as checkpoint inhibitors programmed cell death – 1 receptor (PD-1) and programmed cell deathligand 1 have shown significant responses in multiple malignancies including melanoma, non-small-cell-lung cancer, Hodgkin’s lymphoma to name a few. We present a case of a female patie... view more»
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