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Nikola A Bowden Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
School of Medicine and Public Health, University of Newcastle and Hunter Medical Research Institute, Australia
Biography
Dr. Nikola A Bowden is working as scientist and professor at School of Medicine and Public Health, University of Newcastle and Hunter Medical Research Institute, Australia. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Sequential Decitabine and Carboplatin Induced Stabilisation of Tumour Burden in a Patient with Immunotherapy-Resistant Metastatic Melanoma
Author(s): Andre Van der Westhuizen, Naomi Knoblauch, Moira C Graves, Richard Levy, Luke Hesson, Ricardo E Vilain and Nikola A Bowden
Despite significant progress in the treatment of metastatic melanoma in recent years with targeted and immune checkpoint inhibitor therapy, there is no effective treatment option once resistance to all of these treatments occurs. Here, we report stabilisation of disease in a patient with anti-PD1 immunotherapy resistance after sequential low-dose decitabine and carboplatin. Stable disease allowed for re-challenge with anti-PD1 immunotherapy.
Stable disease with no disease progression was seen in a 47-year old Caucasian male diagnosed with metastatic melanoma with unknown primary who had progressed on previous BRAF/MEK inhibitors (dabrafenib and trametinib) and anti-PD1 immunotherapy (pembrolizumab) after 9 weeks on the novel Phase 2 study (PRIME0... view more»
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