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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Nikolai V Slavine Author
Subjects of specialization
Affiliation
PET Imaging, Imaging, PET, Molecular Imaging , Nuclear Structure
Translational Research Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, USA
Biography
Dr. Slavine is a theoretical physicist. He received his M.S. in theoretical and experimental physics from the Polytechnic University of Tomsk in 1975 and completed his Ph.D. in high energy theoretical physics in 1996 at the Joint Institute for Nuclear Research (JINR) in Dubna. His thesis topic was the use of quark-gluon string model as an approach for describing multiparticle processes in high energy hadron-nucleus interaction.After the completion of his M.S. fellowship.
Publications
Research Article Open Access
Iterative Image Processing for Early Diagnostic of Beta-Amyloid Plaque Deposition in Pre-Clinical Alzheimer’s Disease Studies
Author(s): Nikolai V Slavine, Padmakar V Kulkarni and Roderick W McColl
Purpose: To test and evaluate an efficient iterative image processing strategy to improve the quality of sub-optimal pre-clinical PET images. A novel iterative resolution subset-based method to reduce noise and enhance resolution (RSEMD) has been demonstrated on examples of PET imaging studies of Alzheimer’s disease (AD) plaques deposition in mouse brains.
Materials and Methods: The RSEMD method was applied to imaging studies of non-invasive detection of beta-amyloid plaque in transgenic mouse models of AD. Data acquisition utilized a Siemens Inveon® micro PET/CT device. Quantitative uptake of the tracer in control and AD mice brains was determined by counting the extent of plaque deposition by histological st... view more»
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