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Hindi Clinical Oncology: Case Reports
Nozomu Motono Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan
Biography
Dr. Nozomu Motono is working as scientist and professor at Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Remarkable Effect of Atezolizumab in Advanced Non-Small Cell Lung Cancer with PD-L1 Negative but Genome Instability is Increased: Case Report
Author(s): Nozomu Motono*, Yo Niida, Sohsuke Yamada and Hidetaka Uramoto (Japan)
Immune checkpoint inhibitors have become important paradigms for treating non-small cell lung cancer patients. Although several biomarkers indicating the efficacy of immune checkpoint inhibitors have been reported, these markers sometimes are not accurate concerning the therapeutic effect. A 63-year-old man without a smoking history was diagnosed with lung adenocarcinoma pathological stage IVB without an epidermal growth factor receptor mutation or anaplastic lymphoma kinase translocation, rearrangement of ROS1, or expression of programmed deathligand 1 (PD-L1). Although cytotoxic anticancer therapies were administered, carcinoembryonic antigen (CEA) gradually became elevated, and the lesions progressed. Atezolizumab was administered as third-line chemotherapy, after which CEA normalize... view more»
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