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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Ogunwa Tomisin Happy Author
Subjects of specialization
Affiliation
Biochemistry, Enzymology, Environmental Biochemistry
Centre for Bio-computing and Drug Development, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria
Biography
Ogunwa Tomisin Happy is current working as Academic and research fellow in kungba Akoko, Ondo State. Nigeria. Taught undergraduate courses including Enzymology, Environmental Biochemistry, Introductory Biochemistry I & II, Methods in Biochemistry, etc.and he give seminar on supervision of undergraduate students. He also Served as a staff adviser students' union (NABS). Previously he Served coordinator for First year students. His resaerch intersts includes Biochemistry Natural products and Medicinal chemistry.
Publications
Research Article Open Access
Ab Initio Modeling and Garcinia Biflavonoids-Binding Study of Tyrosinase: The Signature Enzyme of Melanogenesis
Author(s): Ogunwa Tomisin Happy
Hyperpigmentation in humans can result from sun damage, inflammation, or other skin injuries. Tyrosinase, a crucial enzyme which catalyzes the main and rate limiting steps in melanogenesis, is a validated target in the treatment of skin hyperpigmentary disorders. Previously, employing in vitro analysis, inhibitory activities of Garcinia biflavonoid complex (kolaviron) and morelloflavone (a Garcina dulcis biflavonoid) on tyrosinase were observed. In the current study, ab initio modeling was carried out for tyrosinase and the resultant structure was employed in molecular docking to investigate the precise interaction pattern of these biflavonoids on the protein’s putative binding site. The results obtained revealed that the biflavonoids occupied the binding pocket (tropolone binding... view more»
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