Padmakar V Kulkarni Author

Research Article Open Access

Iterative Image Processing for Early Diagnostic of Beta-Amyloid Plaque Deposition in Pre-Clinical Alzheimer’s Disease Studies

Author(s):

Nikolai V Slavine, Padmakar V Kulkarni and Roderick W McColl

Purpose: To test and evaluate an efficient iterative image processing strategy to improve the quality of sub-optimal pre-clinical PET images. A novel iterative resolution subset-based method to reduce noise and enhance resolution (RSEMD) has been demonstrated on examples of PET imaging studies of Alzheimer’s disease (AD) plaques deposition in mouse brains.
Materials and Methods: The RSEMD method was applied to imaging studies of non-invasive detection of beta-amyloid plaque in transgenic mouse models of AD. Data acquisition utilized a Siemens Inveon® micro PET/CT device. Quantitative uptake of the tracer in control and AD mice brains was determined by counting the extent of plaque deposition by histological st... view more»

DOI: 10.4172/2329-9533.1000134

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