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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Palanirajan Vijayaraj Kumar Author
Subjects of specialization
Affiliation
Cancer Cell Lines
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Jalan Menara Gading, UCSI University(South Campus), Taman Connaught, Cheras 56000, Kuala Lumpur, Malaysia
Biography
My name is Palanirajan Vijayaraj Kumar- I am from Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Jalan Menara Gading, UCSI University(South Campus), Taman Connaught, Cheras 56000, Kuala Lumpur, Malaysia My area of interests are Cancer Cell Lines
Publications
Research Article Subscription
Enhanced Cytotoxic Effect of Chemically Conjugated Polymeric Sirolimus against HT-29 Colon Cancer and A-549 Lung Cancer Cell Lines
Author(s): Bontha Venkata Subrahmanya Lokesh and Palanirajan Vijayaraj Kumar
Enhanced Cytotoxic Effect of Chemically Conjugated Polymeric Sirolimus against HT-29 Colon Cancer and A-549 Lung Cancer Cell Lines
Background/Aim
Sirolimus (SR) is highly protein binding drug (92%) and lipophilic (log P=4.917) in nature. It has half life of 57- 63hrs and oral bioavailability is 20% even less when after eating food rich in fat. In our objective of the study, SR is chemically conjugated with biodegradable polymers like methoxy-polyethylene glycolic acid (mPEG COOH) and Poly(... view more»
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