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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Peter James Author
Subjects of specialization
Affiliation
Drug Absorption
Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan
Biography
My name is Peter James- I am from Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotogecho, Hirakata, Osaka 573-0101, Japan My area of interests are Drug Absorption
Publications
Commentary Open Access
Carriers for Prodrug Synthesis
Author(s): Peter James
A prodrug could also be a medicine or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug rather than administering a drug directly, a corresponding prodrug are often used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME).
Many herbal extracts historically utilized in medicine contain glycosides (sugar derivatives) of the active, which are hydrolyzed within the intestines to release the active and more bioavailable aglycone for instance, salicin could also be a β-D-glucopyranoside that's cleaved by esterases to release salicylic acid. Aspirin, aspirin, first made by Felix Hoffmann at Bayer in 1897, could also be an artificial prodrug of salicylic acid.
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