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+44 28 3718 0055Journal of Addictive Behaviors,Therapy & RehabilitationISSN: 2324-9005
Rammohan Shukla Author
Subjects of specialization
Affiliation
Drug Policy and Trends; Mental Health Treatment; , disease diagnosis
Department of Biology, University of Toledo, USA
Biography
Specialization in Food and Nutrition, Food Microbiology, Processing and Preservation, Food Engineering, Food Quality and has published an article entitled An Integrated systems biology approach identifies causal pathways and Neuronal subtypes associated with phasic changes in major depressive disorder.
Publications
Special Issue Article Open Access
An Integrated systems biology approach identifies causal pathways and Neuronal subtypes associated with phasic changes in major depressive disorder
Author(s): Rammohan Shukla
Statement of the Problem: MDD is characterized by heterogeneous symptoms, including low mood, anhedonia and cognitive impairments. The course of the disease often follows a periodic trajectory (Fig1), which includes recurrent episodes of increasing severity, duration, and progressive resistance to antidepressants, separated by gradually shortening partial or full remission phases, often leading to chronic and treatment-resistance depression with deteriorating functional fitness. Notably, studies so far have majorly focused on the differences between control and MDD subjects. Molecular changes in different phases of the MDD largely remains unknown. Methodology & Theoretical Orientation: To address this issue we performed RNAseq of 90 postmortem subgenual anterior cingulate cortex tis... view more»
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