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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Rohit R Joshi Author
Subjects of specialization
Affiliation
Civil Society
Department of Biochemistry and Molecular Biophysics, Columbia University, 701 W. 168th St. HHSC 1104, New York, NY 10032, USA
Biography
My name is Rohit R Joshi I am from Department of Biochemistry and Molecular Biophysics, Columbia University, 701 W. 168th St. HHSC 1104, New York, NY 10032, USA My area of interests are Civil Society
Publications
Research Article Subscription
Anionic Self Micro-Emulsifying Drug Delivery System(SMEDDS) Of Docetaxel for Circulation Longevity
Author(s): Rohit R Joshi and Padma V Devarajan
Anionic Self Micro-Emulsifying Drug Delivery System(SMEDDS) Of Docetaxel for Circulation Longevity
In the present study, we present anionic self microemulsifying drug delivery system (SMEDDS) of DTX for long circulation comprising of ethyl oleate, Tween-80, propylene glycol and dimethyl acetamide. The anionic charge was induced by including two different anionic surface active agents Sodium oleate and Gantrez AN-119 which localized at the oil water interface as evident by the negative zeta potential of -16mV and -26mV respectively. Hemolysis <15% exhibited by SMEDDS confirmed safety for intravenous administration. Intrav... view more»
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