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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Ryong Nam Kim Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Center for Medical Innovation, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Biography
Ryong Nam Kim; Center for Medical Innovation, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. One of his references is, "Lavdovskaia ED, Iyevleva AG, Sokolenko AP, Mitiushkina NV, Preobrazhenskaya EV, et al. (2018) Egfr t790m mutation in tki-naive clinical samples: Frequency, tissue mosaicism, predictive value and awareness on artifacts. Oncol Res Treat 41: 634-642."
Publications
Research Article Open Access
Mutational Mosaicism in Breast Cancer
Author(s): Ryong Nam Kim
In recent years, a huge number of mutational variants had been identified in breast cancer by next-generation sequencing technologies. Even though a considerable portion of them are variants with low variant allele fraction (<30%), which could give rise to suspicion among us regarding whether they might be false or true, recent pioneering studies have begun to corroborate that a certain amount of them are true variants associated with mutational mosaicism. In this study, for the first time, we present pathogenic mutational mosaicism in breast cancer by carrying out comprehensive analysis of large-scale somatic mutation databases far beyond a limited scale of individual cohorts. We identified 23 pathogenic and likely pathogenic mutations with low variant allele fraction (≤ 30%). Of... view more»
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