Sameer Surendra Kasat Author

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Synthesis of Azopolymer for Colon Targeted Drug Release

Author(s):

Sameer Surendra Kasat, Ashok P Pingle, Harpreet Kaur Khanuja, Nidhi Saiwal and Mandeep Dahiya

Background: Colon specific drug delivery system has attracted considerable attention for the past few years to release drugs in a predictable and reproducible manner. To achieve successful drug delivery, a drug needs to be protected from degradation, release and absorption in the upper portion of the gastric intestinal tract and then to be ensured abrupt or controlled release in the proximal colon.

Methods: A system for colonic targeting drug delivery was developed by coating the drug-containing capsules with azo aromatic, microbial degrading and pH-sensitive polymers that are prone to selective degradation in the colon environment. The azo aromatic polymers were synthesized by a bulk polymerization technique using different ratios of water... view more»

DOI: 10.4172/2325-9604.1000166

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