Sandeep Arora Author

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Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Author(s): Bhumika Sharma, Arvind Sharma, Sandeep Arora, Shriya Gupta and Manila Bishnoi

Formulation, Optimization and Evaluation of Atorvastatin Calcium Loaded Microemulsion

Atorvastatin calcium is a HMG-CoA inhibitor having an Antihyperlipidemic effect. It belongs to the II class of BCS classification hence formulating a microemulsion will increase its solubility/ dissolution and thus improves the oral bioavailability. Microemulsion formulation is prepared by water titration method using Labrafil M1944CS, Cremophor RH 40 and Transcutol HP as oil, surfactant and co-surfactant respectively. A single isotropic region, which is considered to be a bicontinuous microemulsion, is found in the pseudoternary phase diagrams developed at various ratios of Labra... view more»

DOI: 10.4172/2325-9604.1000109

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