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Hindi Clinical Oncology: Case Reports
Sarah Picardo Author
Subjects of specialization
Affiliation
cancer, cancer oncology, Carcinogenesis
Department of Medical Oncology, Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
Biography
Dr. Sarah Picardo is working as scientist and professor at Department of Medical Oncology, Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Open Access
Response to PARP Inhibitor in PALB2-Mutated Metastatic Pancreatic Adenocarcinoma: A Case Report
Author(s): Michael J Allen, Amy Zhang, Samuel D Saibil, Sarah Picardo, Shari Moura, Grainne M O’Kane and Jennifer J Knox
Abstract
PALB2 (Partner and Localizer of Breast Cancer Type 2 (BRCA2)) pathogenic variants increase sensitivity to poly (ADP-ribose) Polymerase Inhibitors (PARPi) in a variety of malignancies, yet no documented objective response to treatment in metastatic pancreatic cancer has been reported. We describe a case of a PALB2-mutated metastatic pancreatic cancer patient who had achieved a partial response to platinum-based chemotherapy, and was then observed to achieve an ongoing partial response with a further 42% reduction in tumor size over 6-months of treatment to date whilst on the PARPi olaparib.
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