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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Simeon K. Adesina Author
Subjects of specialization
Affiliation
Human brucellosis;
Department of Pharmaceutical Sciences, Howard University, Washington DC,USA
Biography
Simeon K. Adesina completed his Ph.D. at the Department of Pharmaceutical Sciences, College of Pharmacy, Howard University after obtaining the B. Pharm. (Distinction) and M.Sc. (Pharmaceutics) degrees from the Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife in Nigeria. He has published several articles in peer reviewed journals and has several abstracts and conference proceedings. He has been granted a patent and also has one patent submission.
Publications
Research Article Open Access
Nanoparticle Formulation of Brusatol: A Novel Therapeutic Option for Cancers
Author(s): Simeon K. Adesina
Objective: Challenges to the use of brusatol for cancer chemotherapy include its reversible and short-lived effect on Nrf2 which is limited to a few hours, its non-selective inhibition of protein synthesis which renders it potentially toxic to non-cancerous cells resulting in adverse effects and poor water solubility. A nanoparticle formulation of brusatol is expected to overcome these challenges and facilitate the clinical use of brusatol. In this proof-of-principle study, a brusatol-loaded nanoparticle formulation is developed and characterized.
Method: Brusatol-loaded mPEG-PLGA nanoparticles were prepared using the oil-in-water emulsification solvent diffusion method and characterized.... view more»
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