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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Teh Lay Kek Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor, Malaysia.
Biography
Teh Lay Kek; Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM), Selangor, Malaysia. One of his references is, "Dhanjal JK, Sreenidhi AK, Bafna K, Katiyar SP, Goyal S, et al. (2015) Computational structure-based de novo design of hypothetical inhibitors against the anti-inflammatory target COX-2. PLoS One 10: e0134691."
Publications
Research Article Open Access
High-Throughput Structure-Based Drug Design of Chalcones Scaffolds as Dual Inhibitor of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1
Author(s): Muhd Hanis Md Idris, Siti Norhidayu Mohd Amin, Manikandan Selvaraj, Hisyam Jamari, Teh Lay Kek and Mohd Zaki Salleh*
Cyclooxygenase-2 (COX-2) inhibitors had been extensively used to treat inflammatory disorders. However, the increased incidence of cardiovascular side effects had limited the usage of the drugs. The emergence of microsomal prostaglandin E synthase-1 (mPGES-1) as newly recognized therapeutic target for inflammation and pain gave new hope to develop anti-inflammatory drug with minimal adverse effects. Thus, selective inhibition of COX-2 and mPGES-1 is expected to provide anti-inflammatory effects without the side effects. Chalcone is a compound derived from nature with various pharmacological activities. Based on its favorable activity, chalcone framework had been used to identify novel derivatives for anti-inflammatory properties. Hence, the present study aim... view more»
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