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Tian Yuyao Author
Subjects of specialization
Affiliation
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research
The Chinese University of Hong Kong, Hong Kong
Biography
Tian Yuyao is a PhD pursuing candidate in The Chinese University of Hong Kong, School of Biomedical Sciences Hong Kong. She has completed her master study from Peking University
Publications
Short Communication Open Access
Elucidating the bone developmental defect in Werner Syndrome using stem cells
Author(s): Tian Yuyao, Miu Kai-Kei, Wang Zhangting and Chan Wai Yee
Werner Syndrome (WS) is an autosomal recessive genetic disorder characterized by premature aging. This disease is caused by mutations in the WRN gene. The first sign of WS is short stature. Individuals with WS have an abnormally slow growth rate, and growth stops at puberty. As a result, affected individuals have short stature. However, the mechanism is still not clear. To find out the cause of short stature in WS, the author reprogrammed the WS patients’ fibroblasts and the isogenic normal control into mesenchymal stem cells and compared the transcriptome by RNA-Seq.
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