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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Yang K Xiang Author
Subjects of specialization
Affiliation
Heart Failure, Alzheimer's Disease, Insulin Resistance, GPCR phosphodiesterase
Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Biography
Yang K Xiang is currently working as a Associate Professor Pharmacology. He persude his B from Wuhan University, China and Ph.D. from Oregon Health Science University. Hisresearch focuses on signaling integration of a converged network of insulin receptor and adrenergic receptors, and their roles in different clinical conditions including diabetes, cardiovascular complication and Alzheimer’s disease, respectively.
Publications
Research Article Open Access
Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of Î’2 Adrenergic Receptor Gene
Author(s): Yuan Zhou, Lintao Chen, Xi Zhou, Yechun Pei, Shuangshuang Wei, Anum Mehmood, Yang K Xiang and Dayong Wang
Alzheimer’s disease (AD) is a lifelong progressive neurodegenerative disease related with accumulation of amyloid β peptide (Aβ) produced by processing of amyloid precursor protein (APP) in the brain. In spite of several-decades effort on AD, there is still no medicine used to intervene with its pathological processes. Our previous studies made in transgenic animal models harboring familial AD genes of mutant presenilin 1 and amyloid precursor protein (APP) showed that β2AR gene knock-out (β2AR-KO) is beneficial in senile AD animals. Consistently, an epidemiological study lasted for two decades showed that the sole usage of β blockers as antihypertensive medicines is associated with fewer brain lesions and less brain shrinkage seen in senile AD patients. I... view more»
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