Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

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Younsoo Bae Author

younsoo.bae@uky.edu

Subjects of specialization
Lipophilic Polymer Additives

Affiliation
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, Lexington, KY 40536, USA

Biography

My name is Younsoo Bae  I am from  Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, Lexington, KY 40536, USA My area of interests are  Lipophilic Polymer Additives                   

Publications

Research Article Open Access

Block Copolymer Crosslinked Nanoassemblies Co-entrapping Hydrophobic Drugs and Lipophilic Polymer Additives

Author(s):

Daniel Scott and Younsoo Bae

Block Copolymer Crosslinked Nanoassemblies Co-entrapping Hydrophobic Drugs and Lipophilic Polymer Additives

Block copolymer crosslinked nanoassemblies (CNAs) were synthesized to investigate their patterns of entrapping and releasing an anticancer drug (17-AAG) in the presence of a lipophilic polymer additive (polylactic acid: PLA) in the core. The CNAs were prepared by crosslinking poly (ethylene glycol)-poly (aspartate hydrazide) (PEG-Hyd) block copolymers through an amide bond. The CNAslocked in the particle size after co-entrapping 17-AAG and PLA (< 50 nm in diameter). PLA with various molecular weights (3.4, 6, and 7.5 kDa) was used as polymer additives that are s... view more»

DOI: 10.4172/2325-9604.1000116

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