Zakaria A El-Khayat Author

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Analgesic, Antipyretic and Anti-inflammatory Activities of the Egyptian Spitting Cobra; Naja nubiae Venom

Author(s):

Mohamed M Abdel-Daim, Hanan J A Altawil, Mohamed A Abdel-Rahman, Mohamed S El-Naggar and Zakaria A El-Khayat

Objectives: Although many venomous snakes represent a potential human health threat, their venoms provide a rich source of active components, many of which have been recently identified, and used as potential candidates for pharmacological therapeutic purposes. The current study was designed to evaluate the analgesic, antipyretic and antiinflammatory activities of the Egyptian spitting cobra Naja nubiae venom.

Methods: The venom of N. nubiae was intraperitoneally injected at two dose levels (1/10 and 1/5 LD50). The peripheral and central analgesic effects were examined using acetic acidinduced abdominal writhing in mice and tail immersion test in rats, respectively. Brewer’s yeast-induced pyrexia in rats was carried... view more»

DOI: 10.4172/2325-9841.1000133

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