Zeev Volkovich Author

Research Article Open Access

Testing the Metagenome Composition by the Method of Sequential Set of Primers

Author(s):

Valery Kirzhner, Zeev Volkovich, Renata Avros and Elena Ravve

Metagenome is a mixture of different genomes and the analysis of its composition is, currently, a challenging problem of bioinformatics. In the present study, we attempt to solve this problem using DNAmarker primers-short nucleic acid fragments. Formally speaking, each primer maps a genome into a finite set of integral numbers. This set is called the genome spectrum for the given primer and is unique for each genome. The union of the genetic material of two genomes is mapped into the union of their spectra. Thus the metagenome spectrum always includes (covers) the spectra of the constituting genomes. A genome whose spectrum is not covered by the metagenome one, cannot be part of the metagenome, while the spectrum of a genome that is not included in the metagenome can accidentally be cov... view more»

DOI: 10.4172/2329-9533.1000150

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