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A Complete Response to Immune Checkpoint Therapy in A Treatment Refractory Patient with Metastatic Pancreatic Cancer and Mismatch Repair Deficiency | SciTechnol

Clinical Oncology: Case Reports.

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Case Report, Clin Oncol Case Rep Vol: 3 Issue: 6

A Complete Response to Immune Checkpoint Therapy in A Treatment Refractory Patient with Metastatic Pancreatic Cancer and Mismatch Repair Deficiency

Nicholas Jette1*, Adam Fundytus2 and Jose Monson3

1Cumming School of Medicine, University of Calgary, Calgary, Canada

2Division of Cancer Care and Epidemiology, Queen's University, Canada

3Medical Oncologist, Tom Baker Cancer Centre, Canada

*Corresponding Author:
Nicholas Jette
Cumming School of Medicine
University of Calgary, Calgary, Canada
E-mail: nrjette@ucalgary.ca

Received: December 01, 2020 Accepted: December 15, 2020 Published: December 22, 2020

Citation: Jette N, Fundytus A, J Monson J (2020) A Complete Response to Immune Checkpoint Therapy in a Treatment Refractory Patient with Metastatic Pancreatic Cancer and Mismatch Repair Deficiency. Clin Oncol Case Rep 4:1

Abstract

Abstract

Pancreatic cancer remains a difficult to treat malignancy. Advanced application of targeted chemotherapeutics has extended survival but has not resulted in cure. Recently, the application of immunotherapy has shown promise in cancers that harbour mismatch repair deficiencies and micro-satellite instability. Here, we show a metastatic pancreatic cancer with a mismatch repair deficiency respond dramatically to PD-1 inhibitor therapy.

Keywords: Pancreatic cancer; Chemotherapy; Precision oncology; Mismatch repair; Micro-satellite instability; PD-1

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