Clinical Oncology: Case ReportsJournal of Oncology

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Case Report, Clin Oncol Case Rep Vol: 5 Issue: 8

A Rare Case of Germinoma Involving Suprasellar Region: A Clinical Case Report

Avinash Vallepalli*, Rohit Patil and Kamalksh Shenoy

Department of Radiation Oncology, of medical sciences and research centre, Mangalore, India.

*Corresponding Author: Avinash Vallepalli
Department of Radiation Oncology, of medical sciences and research centre, Mangalore, India. E-mail:

Received: August 03, 2022; Manuscript No: COCR-22-71210;
Editor Assigned: August 05, 2022; PreQC Id: COCR-22-71210 (PQ);
Reviewed: August 19, 2022; QC No: COCR-22-71210 (Q);
Revised: August 21, 2022; Manuscript No: COCR-22-71210 (R);
Published: August 27, 2022; DOI: 10.4172/cocr.5(8).246

Citation: Vallepalli A (2022) A Rare Case of Germinoma Involving Suprasellar Region: A Clinical Case Report. Clin Oncol Case Rep 5:8


The incidence of intracranial germinomas is less than 1% of all intracranial neoplasms. Germinomas do not commonly occur in a suprasellar location. The presence of diabetes insipidus and visual disturbance as an early symptom has been reported in almost all patients of suprasellar germinomas and may help in distinguishing these tumours from other suprasellar lesions, Radiological studies such as MRI and biochemical markers help in the diagnosis of germinoma. Although they are extremely radiosensitive, chemotherapeutic agents aid in shrinking the tumour and reducing irradiated volume Which is particularly important in younger children to avoid post-irradiation endocrinological disturbances.

Keywords: Germinoma; Suprasellar; Intracranial neoplasm; Radiosensitive; Radiation therapy and chemotherapy


Germinoma is the most common type of intracranial Germ Cell Tumor (GCTs). The pineal gland and suprasellar region are the most frequent sites of Central Nervous System (CNS) involvement. Suprasellar germinomas are a unique type of uncommon brain tumour in children [1]. Most of these tumours develop along the midline, most often from the pineal gland, followed by tumours arising in the suprasellar cisterns. Suprasellar germinomas commonly manifest with diabetes insipidus, visual impairment, and hypothalamicpituitary failure. Suprasellar germinomas are highly curable lesions when diagnosed early [2]. The treatment remains controversial and should be individualized, but the association of chemotherapy and radiotherapy allows reduce adverse effects and shows great results.

Case Report

A 17 years old female, came with a history of blurring of vision, double vision in the left visual field and headache since 2 years which gradually progressed over months. One month just before the presentation, symptoms worsened hence she was evaluated and was found to have a brain lesion and underwent Right fronto temporal craniotomy and biopsy of a suprasellar lesion. She has not yet attained menarche at the time of evaluation. No similar complaints in the past and no other known medical co-morbidities.

Diagnostic Assessment

Fundoscopy revealed a bilateral pale optic disc suggestive of primary optic atrophy. MRI revealed evidence of an altered signal intensity area measuring 2.9 cm×3.6 cm×4.3 cm noted in Sella, which is isointense on T1, heterogeneously hyperintense on T2 and FLAIR images showing diffusion restriction with no evidence of SWI blooming. Post-contrast study shows heterogeneous enhancement with non-enhancing areas within. Posteriorly extending to posterior cranial fossa along clivus. Suggestive of Pituitary Macro adenoma, CT scan showed Ill-defined mass lesion measuring 4.2 cm×3.8 cm×3.1 cm noted in sellar region with extension to the suprasellar and parasellar and causing Obstructive Hydrocephalus. The frozen section is a Cytological feature suggestive of germinoma. Histopathology is a feature consistent with germinoma of sella-suprasellar area. IHCPLAP positive in tumour cells, MIB1-labelling is high. CSF B-HCG 15.67 mIu/ml (Figure 1 and 2).


Figure 1: Shows histopathology of germinoma.


Figure 2: Pre biopsy MRI showing lesion.

Therapeutic Intervention

After giving proper counselling about disease & treatment, the Patient underwent a Right Ventriculo-Peritoneal shunt followed by a right fronto-temporal craniotomy and biopsy of the suprasellar region.

She was then planned for Adjuvant chemotherapy as per Children's Oncology Group ACNS 1123 protocol and received INJ CARBOPLATIN 600mg/m² and INJ ETOPOSIDE 150mg/m² on D1- D3 for a total of 4 cycles every 3 weeks. She was re-evaluated with MRI which was suggestive of partial response to chemotherapy, Hence she was planned for CSI with a dose of 24Gy in 15# over 3 weeks and boost to residual disease to dose of 16 Gy in 10# over 2 weeks (Figure 3-5).


Figure 3: 3D-CRT plan for cranio-spinal irradiation.


Figure 4: Shows boost to residual disease.


Figure 5: Shows Dose Volume Histogram (DVH).


Germinomas are most commonly seen in adolescents and young adults: 90% of patients are younger than 20 years. There is no gender preference for the suprasellar location, unlike the pineal location with male predominance. Clinical symptoms include diabetes insipidus, precocious puberty, or growth failure related to hypothalamic involvement and visual loss provoked by chiasmatic compression [3]. Large lesions can cause hydrocephalus by obstruction of the interventricular foramens. Multifocal germinomas usually involve the pineal gland and the suprasellar cistern, simultaneously or not. Leptomeningeal spread with drop metastases along the spinal cord are reported. Before treatment, a complete survey of the brain and spinal canal is required because germinomas can metastasize by subarachnoid seeding [4]. A repeat MRI examination is required in 3 months to 6 months. Early diagnosis may reduce the risk of dissemination and the morbidity of treatment. In our case patient received chemotherapy followed by Radiation therapy which has shown good response.


Suprasellar Germinoma is a rare occurrence and has a good survival rate due to advances in chemotherapy and radiation therapy techniques. Proper counselling about disease and treatment should be made to the patient. Even with rarity of the disease, we have treated the patient radically with curative intent and have found excellent results.


  1. Esfahani DR, Alden T, DiPatri A, Xi G, Goldman S, et al. (2020) Pediatric suprasellar germ cell tumours: A clinical and radiographic review of solitary vs. bifocal tumors and its therapeutic implications. Cancers 12: 2621. [Google Scholar] [Cross Ref]
  2. Seilanian-Toosi F, Aminzadeh B, Faraji-Rad M, Nekooei S, Nahidi M, et al. (2018) Pineal and suprasellar germinoma cooccurence with vertebra plana: A case report. Brain Tumor Res Treat 6: 73-77. [Google Scholar] [Cross Ref]
  3. Mesquita-Filho PM, Santos FP, Köhler LR, Manfroi G, De Carli F, et al. (2018) Suprasellar germinomas: 2 case reports and literature review. World Neurosurg 117: 165-171. [Google Scholar] [Cross Ref]
  4. Bonneville JF, Bonneville F, Cattin F, Nagi S. (2016) MRI of the pituitary gland. Cham: Springer Internat Pub. [Google Scholar]
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