Journal of Blood Research & Hematologic Diseases

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Short Communication, Jbrhd Vol: 6 Issue: 6

Association of 8 Snps with Metabolic Changes in Type 2 Diabetes Mellitus in the Kazakh Population

Almagul Nagimtayeva

Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Kazakhstan

Abstract

Introduction: The steady growth of patients with type 2 diabetes mellitus (T2D) in the Republic of Kazakhstan over the past decade indicates the need to develop a program for the prevention of T2D. A change in the expression of candidate genes can lead to impaired insulin synthesis, a decrease in the number of insulin receptors, β-cell dysfunction, and obesity. The purpose of this study is to analyze the association of the SNPs with biochemical and anthropometric parameters of T2D in representatives of the Kazakh population.

Keywords:

Introduction: The steady growth of patients with type 2 diabetes mellitus (T2D) in the Republic of Kazakhstan over the past decade indicates the need to develop a program for the prevention of T2D. A change in the expression of candidate genes can lead to impaired insulin synthesis, a decrease in the number of insulin receptors, β-cell dysfunction, and obesity. The purpose of this study is to analyze the association of the SNPs with biochemical and anthropometric parameters of T2D in representatives of the Kazakh population.

Materials and methods: In total, 139 patients with T2D and 100 randomly selected patients with no signs of disease were registered in the current study. Cases of T2D are diagnosed based on World Health Organization criteria. The samples were ethnically homogeneous and included only the Kazakhs. The biochemical (total cholesterol, LDL, HDL, glucose and HOMA-IR index) and anthropometric indicators were evaluated.

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