Journal of Blood Research & Hematologic Diseases

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Case Report, J Blood Res Hematol Dis Vol: 3 Issue: 1

Autoimmune Diseases And Rosai- Dorfman Disease Coexist More Commonly Than Expected

Lia NL1*, Asad SD2, Jafri SI3 and Harrison JS3

1Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, USA

2Department of Neurology, University of Connecticut School of Medicine, Farmington, USA

3Department of Medicine and the Carole and Ray Neag Cancer Center, University of Connecticut School of Medicine, Farmington, USA

*Corresponding Author : Nerea Lopetegui Lia
Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA
E-mail: [email protected]

Received: December 11, 2018; Accepted: January 07, 2019; Published: January 14, 2019

Citation: Lia NL, Asad SD, Jafri SI, Harrison JS (2019) Autoimmune Diseases and Rosai-Dorfman Disease Coexist More Commonly than Expected. J Blood Res Hematol Dis 3:1. doi: 10.4172/jbrhd.1000114


The educational objective herein is to describe 2 case reports in which patients were found to have an autoimmune disease concomitantly with a rare, benign histiocytic disorder known as Rosai-Dorfman disease (RDD). It is unclear if there is an underlying association between autoimmune disease and RDD, as the pathophysiology of RDD has not been well defined to date. Regardless, autoimmune diseases are relatively common in the general population; hence RDD should remain within the differential diagnosis when lymphadenopathy is seen. Lymphadenopathy, although most frequently seen bilaterally in the cervical region in RDD, may present anywhere. A biopsy with histologic confirmation is required to not only evaluate for malignancy in these cases but also necessary to diagnose RDD. Further basic scientific and clinical research is required to fully understand all the characteristics and optimal management of RDD disease. However, we have observed in these two cases presented, that if the autoimmune disease is well controlled, RDD can be an indolent disease.

Keywords: Rosai-Dorfman disease; Autoimmune disease; Lymphadenopathy; Histiocytosis

international publisher, scitechnol, subscription journals, subscription, international, publisher, science

Track Your Manuscript

Recommended Conferences

open access