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Case Report, Clin Dermatol Res J Vol: 1 Issue: 1

Extravasation with Trabectedin(Yondelis: ET-743) Troubles with the Use of Cytostatic Agents

Alejandro Lobato-Berezo1*, Amparo Lucena-Campillo2, Francisco Hidalgo2 and Antonio Aguilar-Martínez1
1Department of Dermatology, Hospital Universitario Severo Ochoa, Spain
2Department of Pharmacy, Hospital Universitario Severo Ochoa, Spain
Corresponding author: Alejandro Lobato Berezo
Department of Dermatology, Hospital Universitario Severo Ochoa, 28911 Leganés (Madrid), Spain
E-mail: [email protected]
Received: February 23, 2016 Accepted: April 02, 2016 Published: April 07, 2016
Citation: Lobato-Berezo A, Lucena-Campillo A, Hidalgo F, Aguilar-Martínez A (2016) Extravasation with Trabectedin (Yondelis: ET-743) Troubles with the Use of Cytostatic Agents.Clin Dermatol Res J 1:1.

Abstract

Extravasation with Trabectedin (Yondelis: ET-743) Troubles with the Use of Cytostatic Agents

 

The use of chemotherapeutic agents can be the cause of local or systemic toxicity.  Extravasation is a serious phenomenon which can lead to chronic and irreversible side- effects. In 2007, trabectedin (Yondelis®; ET- 743) obtained a commercial license of the European Medicines Agency (EMA) for the treatment of adult patients with advanced soft tissue sarcoma after failure of anthracyclines and ifosfamide or who are unsuited to receive these agents. Since 2009, trabectedin in combination with pegylated liposomal doxorubicin (PLD) is also indicated for the treatment of patients with relapsed platinum-sensitive ovarian cancer. We report a case of an ovarian cancer patient with a cytotoxic reaction due to an extravasation of trabectedin. This situation has been rarely reported in the literature. To our knowledge, there is only one reference with two cases of an identical type of extravasation with the same product.

Keywords: Trabectedin; Chemotherapy; Cytostatic agent; Extravasation

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